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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
October 31, 2025
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A myPBCteam Member

I cannot tolerate Ursodiol. I take TUDCA. I also take 10 mg Livdelzi. They initially reduced my alk phos about 250 points. If I stop taking it, my alk phos goes back up. I do not have cirrhosis.

October 31, 2025
myPBCteam

What dosage of Livdelzi are you taking, and are you combining it with Urso?

Livdelzi (seladelpar) is a newer PBC medication that can be taken either alone or in combination with ursodiol (Urso). It's typically prescribed for people who haven't responded well to ursodiol alone or can't tolerate it due to side effects.

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What dosage of Livdelzi are you taking, and are you combining it with Urso?

Livdelzi (seladelpar) is a newer PBC medication that can be taken either alone or in combination with ursodiol (Urso). It's typically prescribed for people who haven't responded well to ursodiol alone or can't tolerate it due to side effects.

The specific dosing of both medications varies by individual and should be determined by your healthcare provider based on your liver function tests and how well you're responding to treatment.

When combining these medications, your doctor will monitor your liver enzyme levels, particularly ALP (alkaline phosphatase), to see how well the treatment is working for you. They may adjust dosages based on your response and any side effects you experience.

Have you noticed any changes in your symptoms or side effects since starting Livdelzi? Your doctor can help determine the best dosing strategy for your specific situation.

October 31, 2025

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