Should you worry about your ALP rising from 167 to 175?
It's understandable to feel concerned, but a small increase like this doesn't necessarily mean treatment is failing. Your doctor will be looking at the bigger picture, including how your ALP compares to the upper limit of normal (ULN) and whether it stays elevated Show Full Answer
Should you worry about your ALP rising from 167 to 175?
It's understandable to feel concerned, but a small increase like this doesn't necessarily mean treatment is failing. Your doctor will be looking at the bigger picture, including how your ALP compares to the upper limit of normal (ULN) and whether it stays elevated over time.
PBC is typically diagnosed when ALP levels are at least 1.5 times higher than the normal range. The normal ALP range is 44 to 147 international units per liter, so your level of 175 is still elevated but not dramatically high. Is Urso considered effective at your current ALP level?
Urso (ursodiol/UDCA) is generally considered effective when it brings ALP down to less than twice the normal limit. People with lower ALP levels tend to respond better to treatment.
Your doctor will likely evaluate your response after one year on Urso. If your ALP remains high after that time, or if your bilirubin levels start rising, they may consider adding another medication to your treatment plan. What else can you do to lower ALP?
If Urso alone isn't bringing your ALP down enough after a year or more, newer medications can be added to your treatment. These include:
* Obeticholic acid (OCA)
* PPAR agonists
* Other emerging therapies
These medications are typically considered when ALP stays high despite being on Urso, or if you can't tolerate Urso due to side effects. Most can be used alongside Urso for better results.
Since you're only six months in, give it a bit more time and keep working closely with your doctor to monitor your progress.
January 14
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