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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
April 12
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A myPBCteam Member

Hi Cathie. Thanks for the information. I have sent a message to my doctor. I'll follow up next week.

April 12
A myPBCteam Member

Hi Mary. I have been taking URSODIAL for 24 years and this is the first time I have had this pain. I'll ask my doctor about this. I'm supposed to do an MRI with and without contrast. It's many the liver but I'll ask if it's showing the gallbladder, also. Thanks for the information.

April 15
A myPBCteam Member

Hi Lorraine ! Before taking ursodiol I had pain in my upper right and back area. Now at times I just have pain in my back. I read back pain can be a side effect of ursodiol. I pray you get some answers and feel better soon. 🙏❤️

April 15
A myPBCteam Member

This sounds more like gall bladder pain. Check with your Dr ASAP

April 12
myPBCteam

What does liver pain from PBC feel like?

Liver pain with PBC typically occurs in the upper right part of your abdomen, where your liver sits below your rib cage. The pain can feel dull and achy, or sharp and stabbing. Some people describe it as a tender area that hurts when pressure is applied.

The pain doesn't always Show Full Answer

What does liver pain from PBC feel like?

Liver pain with PBC typically occurs in the upper right part of your abdomen, where your liver sits below your rib cage. The pain can feel dull and achy, or sharp and stabbing. Some people describe it as a tender area that hurts when pressure is applied.

The pain doesn't always stay in one spot. It can radiate to your back, shoulder blades, neck, or even across your upper abdomen. A myPBCteam member asked if others experience upper-right quadrant pain in their back too, and many confirmed this happens.

The pain may come and go unpredictably. Some members report it wakes them at night or stops them in their tracks during daily activities. Others notice it especially when eating or when their abdomen touches something like a counter. Why does PBC cause liver pain?

The pain comes from inflammation and swelling in your liver caused by PBC. Since the liver itself has no nerves, the discomfort actually comes from damage or inflammation of nearby tissues.

Liver pain in PBC may be related to:
- Liver inflammation from the autoimmune process
- Ascites (fluid buildup in your abdomen)
- An enlarged spleen
- Changes to the liver's outer surface

Over time, inflammation leads to fibrosis (scar tissue), which can cause additional complications that contribute to pain. Should you be concerned about new pain?

Yes, you should report new liver pain to your doctor, especially since it's recently started. New or worsening pain could indicate a PBC flare-up or other liver-related issues that need attention.

You should especially contact your doctor if you notice other symptoms alongside the pain, such as:
- Swollen legs, ankles, or feet
- Increased fatigue
- Itchy skin
- Abdominal bloating or rapid weight gain
- Any sharp, intense pain that disrupts your activities

Your doctor can evaluate what's causing your pain and help you find ways to manage it effectively.

April 12

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Shreveport, LA