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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I have a question about Ursodiol.I ve been on ursodiol for 14 years, i s there medical complications with using for so long?

A myPBCteam Member asked a question 💭
Pine City, NY
April 13
 · 
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A myPBCteam Member

Ursodiol has three powers 1) Displace:It dilutes bile and makes it less damaging by removing toxins 2) Flush : Stimulates healthy bile flow and flushes out of bile ducts.
3) protects liver cell death flushing toxic bile acid. It slows the process.
It is a lifetime drug. Your Doctor may change the dose if needed.
Watch TC Hale on u tube talk about bile flow. He talks about food, beet flow, foods that help keep the bile flowing and foods that can clog and thicken.

April 14
myPBCteam

Is there a risk of medical complications from taking ursodiol for 14 years?

Ursodiol is generally considered safe for long-term use in treating PBC. It's designed to be taken continuously to help protect your liver and slow disease progression. Many people take it for years or even decades as part of their ongoing treatment Show Full Answer

Is there a risk of medical complications from taking ursodiol for 14 years?

Ursodiol is generally considered safe for long-term use in treating PBC. It's designed to be taken continuously to help protect your liver and slow disease progression. Many people take it for years or even decades as part of their ongoing treatment plan.

The most common side effects include:
- Diarrhea
- Stomach pain
- Nausea
- Dizziness
- Back pain

These side effects can occur at any time during treatment, but ursodiol doesn't typically cause new complications simply from being used long-term.

That said, researchers are still studying its long-term safety and effects. If you're experiencing new or worsening symptoms after 14 years on the medication, it's important to discuss them with your healthcare provider. They can help determine whether any issues are related to the medication, your PBC progression, or other factors.

Your doctor may also want to monitor your liver function regularly to ensure the medication continues working effectively for you.

April 13
A myPBCteam Member

Thanks Deborah for the utube reference!!

April 15
A myPBCteam Member

I have been on it since 1992 and it’s part of my life and by that I mean I have no side effects and will be on it for the rest of my life.

April 14 (edited)

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