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I recently had a fibroscan and ultrasound since I’ve been on meds for 1 1/2 yrs.
My fibroscan results were great but my ultrasound showed Cirrhotic liver with heterogeneous parenchymal echotexture.
Has anyone else had this experience?

August 13
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A myPBCteam Member

YES, I have overlapping PBC & Autoimmune Hepatitis along with Raynauds, Edema, Venous Insufficiency and I started having symptoms of Sjorens, im miserable. And, that horrible deep itch has started.

September 1
myPBCteam

It's great that your fibroscan results came back looking good — that's genuinely encouraging news! The ultrasound finding of a heterogeneous liver texture can sound alarming, but it's worth knowing that imaging results don't always tell the full story on their own.

Having both PBC and autoimmune hepatitis (overlap Show Full Answer

It's great that your fibroscan results came back looking good — that's genuinely encouraging news! The ultrasound finding of a heterogeneous liver texture can sound alarming, but it's worth knowing that imaging results don't always tell the full story on their own.

Having both PBC and autoimmune hepatitis (overlap syndrome) is something other myPBCteam members have navigated. Researchers estimate that roughly 2% to 19% of people with PBC may also show features of autoimmune hepatitis, so while it's not super common, you're definitely not alone. One important thing to be aware of with overlap syndrome is that people with both conditions can sometimes experience faster progression, which makes ongoing monitoring really important. Key things your doctor will likely keep an eye on include:

- ALT and AST levels — elevated levels can be a sign of autoimmune hepatitis activity
- IgG, ANA, or ASMA antibody levels
- ALP and GGT levels — more closely tied to PBC
- Liver biopsy, if needed, to get a clearer picture

The good news is that treatment options exist for overlap syndrome, often combining UDCA (your PBC medication) with additional medications to manage the autoimmune hepatitis side of things.

Bringing these ultrasound results to a hepatologist — a liver specialist — would be a really worthwhile next step if you haven't already, so they can look at the full picture alongside your fibroscan and blood work.

August 13
A myPBCteam Member

It sounds like a massive other disease when known that way ... but can mean fibrosis,inflammation beginnings, fibrosis. It's GREAT if there's no symptoms yet... then it's very controllable right now by you and following Dr orders!! Good luck...God bless!!

August 16

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Greenville, SC

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