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To diagnose PBC, you need to meet at least two of these three criteria: elevated ALP levels at least 1.5x above normal, positive AMA with titer of 1:40 or higher, or a liver biopsy showing PBC-related damage. While you have a positive AMA test, your ALP levels are normal, which means additional testing may be needed for a Show Full Answer

To diagnose PBC, you need to meet at least two of these three criteria: elevated ALP levels at least 1.5x above normal, positive AMA with titer of 1:40 or higher, or a liver biopsy showing PBC-related damage. While you have a positive AMA test, your ALP levels are normal, which means additional testing may be needed for a definitive diagnosis.

The fact that your GGT (gamma-glutamyl transferase) levels are decreasing is a positive sign, but this alone isn't enough for diagnosis. A liver biopsy might be recommended since you have a positive AMA but normal ALP. During this procedure, a small tissue sample would be taken from your liver to examine under a microscope. This can help determine if there are signs of PBC-related damage and inflammation, and can also help determine prognosis by showing the level of liver fibrosis if present.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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