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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Who is taking OCALIVA?

A myPBCteam Member asked a question 💭
Reston, VA

I read today that OCALIVA is being voluntarily withdrawn from the market. I have been on it for over a year. Is there a substitute for Ocaliva? I have reached out to my gastroenterologist for a new med. Anyone else have any ideas? Thanks everyone!!!

September 11, 2025
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Reactions
A myPBCteam Member

Thank you, Jan! I received a call that they will refill my current prescription, so I have one more month. My doctor should be getting back to me in the next day or so.

September 11, 2025
A myPBCteam Member

Thanks everyone for input. My doctor said he will keep me on Ocaliva until it is no longer available. The he will prescribe Iqirvo. I have been on Ursodial since I was diagnosed 4 years ago. I also take Imuran. As for the Ocaliva, I have not had any side effects.

September 17, 2025
A myPBCteam Member

Hello what has been your experience with it? I don't like the way it makes me feel. I'm looking for another alternative to try...any suggestions?

September 17, 2025
A myPBCteam Member

My doctor just took me off of it. I’m thinking it’s because I recently was diagnosed stage four. I’m now taking Iqirvo.

September 11, 2025
myPBCteam

Yes, there are alternative treatment options available for PBC. The main alternatives include:

• Ursodeoxycholic acid (UDCA/ursodiol) - the first-line treatment for PBC
• Elafibranor (Iqirvo) - newly approved in 2024
• Seladelpar (Livdelzi) - also newly approved in 2024 It's important to note that Elafibranor works by Show Full Answer

Yes, there are alternative treatment options available for PBC. The main alternatives include:

• Ursodeoxycholic acid (UDCA/ursodiol) - the first-line treatment for PBC
• Elafibranor (Iqirvo) - newly approved in 2024
• Seladelpar (Livdelzi) - also newly approved in 2024 It's important to note that Elafibranor works by blocking bile acid production and has shown promising results in clinical trials by reducing ALP levels. This is a very recent treatment option that your gastroenterologist may consider as an alternative.

Reaching out to your gastroenterologist was absolutely the right step to determine the best alternative treatment plan for your specific situation. They can evaluate your individual case and help transition you to the most appropriate medication.

September 11, 2025

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