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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Encephalopathy

November 21, 2025
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Brain Fog and the Liver: Is It a Symptom of PBC? Read Article...
A myPBCteam Member

Has the doctor checked your ammonia levels? I was put on Xifaxon and mental fog cleared.

November 24, 2025
myPBCteam

Do skull depressions occur with hepatic encephalopathy (HE)?

Hepatic encephalopathy doesn't typically cause physical depressions or changes in your skull. HE affects brain function due to toxin buildup when the liver isn't working properly, but it doesn't alter skull structure.

If you're noticing depressions or changes in Show Full Answer

Do skull depressions occur with hepatic encephalopathy (HE)?

Hepatic encephalopathy doesn't typically cause physical depressions or changes in your skull. HE affects brain function due to toxin buildup when the liver isn't working properly, but it doesn't alter skull structure.

If you're noticing depressions or changes in your skull, it's important to discuss this with your doctor. This could be related to other factors, including age-related changes, but it would need medical evaluation to determine the cause.

What is hepatic encephalopathy?

With late-stage PBC, hepatic encephalopathy can develop. This condition causes cognitive symptoms like confusion, memory problems, and personality or mood changes. It happens when toxins that your liver would normally filter build up in your body and affect your brain.

The good news is that hepatic encephalopathy can be managed with specific laxatives or antibiotics that help clear extra toxins from your body.

About cognitive behavioral therapy:

While the search results don't specifically define cognitive behavioral therapy, mental health support is important when living with PBC. Therapists, psychologists, and psychiatrists can help you cope with symptoms and concerns about the future. Mental health is just as important as physical health when managing a chronic condition.

If you're experiencing confusion, mood changes, or personality changes, reach out to your doctor right away so they can evaluate and help you.

November 21, 2025

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