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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
December 13, 2025
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Can PBC cause gallstones or blocked bile ducts?

Yes, gallstones and blocked bile ducts can occur with PBC. In fact, gallstones are a recognized complication of PBC itself.

Here's how PBC contributes to these issues:

- PBC causes inflammation and damage to the bile ducts in your liver
- This inflammation can lead to Show Full Answer

Can PBC cause gallstones or blocked bile ducts?

Yes, gallstones and blocked bile ducts can occur with PBC. In fact, gallstones are a recognized complication of PBC itself.

Here's how PBC contributes to these issues:

- PBC causes inflammation and damage to the bile ducts in your liver
- This inflammation can lead to blockages and bile buildup
- When bile builds up and can't flow properly, it may harden into gallstones
- Bile duct stones and gallstones are listed as common complications of PBC

So PBC itself can increase your risk of developing gallstones, rather than just being a coincidence. Does Ursodiol (Urso) contribute to gallstones?

Ursodiol doesn't typically cause gallstones or blocked bile ducts. In fact, it's prescribed to help improve bile flow in PBC.

However, some myPBCteam members have reported digestive side effects from Urso, including:

- Extreme bloating
- Gas
- Stomach discomfort

These digestive symptoms are different from gallstones or blocked ducts, though they can be uncomfortable. If you're experiencing new or worsening symptoms, it's important to discuss them with your doctor to determine the cause and whether any adjustments to your treatment might help.

December 13, 2025

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