Urso is prescribed by your body weight so the dose can only be adjusted for that but there are other medications as some people do not tolerate Urso well. I would definitely speak with your doctor.
May 18
Do you think my medication needs lower ..my bloods are well down
May 15
That sounds really exhausting and uncomfortable — and it's completely understandable to be concerned after a couple of weeks of this. Digestive issues like diarrhea, nausea, and loss of appetite are known side effects of ursodeoxycholic acid (UDCA), and other myPBCteam members have shared similar experiences.
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That sounds really exhausting and uncomfortable — and it's completely understandable to be concerned after a couple of weeks of this. Digestive issues like diarrhea, nausea, and loss of appetite are known side effects of ursodeoxycholic acid (UDCA), and other myPBCteam members have shared similar experiences.
One myPBCteam member said: "I get diarrhea and stomach cramps shortly after eating and taking ursodiol. Does anyone else have this issue?" — and another replied, "Yes, ever since I started it. No matter what I eat." The good news is there are some things that have helped others manage this:
- Timing the dose — switching to taking it at night helped some people
- Reducing fat intake — high-fat foods can make diarrhea worse with PBC, since fat is already harder to digest
- Dose adjustment — one myPBCteam member worked with their doctor to lower the dose, taken twice daily, which helped significantly
Since this has been going on for a couple of weeks and is affecting your ability to eat, it's really important to contact your doctor soon. Persistent diarrhea can affect how well your body absorbs the medication, which matters for managing PBC effectively.
Please don't adjust your dose on your own — but do let your doctor know what's happening so they can help find the right solution for you.
May 15
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