Fatigue is one of the most common symptoms of PBC, affecting around 65% of people with the condition. Up to 20% experience severe fatigue that can significantly impact daily life — work, school, and favorite activities can all take a hit.
PBC-related fatigue isn't just feeling tired after a long day. It can show up as:
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Fatigue is one of the most common symptoms of PBC, affecting around 65% of people with the condition. Up to 20% experience severe fatigue that can significantly impact daily life — work, school, and favorite activities can all take a hit.
PBC-related fatigue isn't just feeling tired after a long day. It can show up as:
- Ongoing muscle weakness
- Brain fog or trouble concentrating
- Memory lapses
- Lack of motivation
- Poor sleep quality Experts believe PBC fatigue comes in two forms. Central fatigue stems from the brain and nervous system, often linked to cholestasis slowing bile flow. Peripheral fatigue involves muscle weakness and is thought to be related to higher lactic acid levels in the muscles.
Several factors can make fatigue worse, including:
- Poor sleep (over half of people with PBC have a sleep disorder)
- Itching that disrupts sleep
- Nutrient deficiencies (especially vitamins A, D, E, and K)
- Thyroid problems, which are a common comorbidity of PBC
- Certain medications used to manage PBC complications The good news is there are strategies that can help manage fatigue. A myPBCteam member shared: *"I do believe that physical activity plays an enormous role."*
Some helpful approaches include:
- Gentle exercise — even a 5-minute walk can improve energy and stamina over time
- Improving sleep habits — reducing screen time before bed and practicing good sleep hygiene
- Eating a balanced diet — ask your doctor about checking for nutrient deficiencies
- Reviewing your medications — some may contribute to fatigue; your doctor can adjust timing or dosage
- Treating comorbidities — conditions like thyroid issues may need their own treatment
Always check with your healthcare provider before starting a new exercise routine or making major dietary changes, as some changes can affect your liver.
July 18
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