Yes, both PBC and cirrhosis (the scarring that can develop as PBC progresses) can affect the skin in several ways. About 40% of people with PBC experience skin-related symptoms.
Here are the skin changes that can occur:
- Dry skin — Bile buildup in the bloodstream interferes with fat absorption, which dries out the skin
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Yes, both PBC and cirrhosis (the scarring that can develop as PBC progresses) can affect the skin in several ways. About 40% of people with PBC experience skin-related symptoms.
Here are the skin changes that can occur:
- Dry skin — Bile buildup in the bloodstream interferes with fat absorption, which dries out the skin
- Itching (pruritus) — Excess bile salts irritate the nerves in the skin, often affecting the hands and feet first
- Jaundice — A yellowing of the skin and eyes caused by bilirubin buildup
- Hyperpigmentation — Skin darkening unrelated to sun exposure
- Xanthomas — Small, waxy yellow bumps around the eyes, elbows, or knees
- Easy bruising or tearing — Poor absorption of vitamin K (needed for clotting) can make skin fragile
- Spider angiomas — Red, spider-web-like blood vessels just under the skin, linked to portal hypertension in later stages A myPBCteam member described their experience this way: "Fatigue, joint pain, dizziness, mood changes, stomach pain, stomach swelling, and once in a while a yellow tint to my skin."
Managing these symptoms often involves treating the underlying PBC itself. A doctor may also prescribe medications like cholestyramine to help reduce bile in the bloodstream and ease itching and dryness. It's always worth discussing any new or worsening skin changes with your doctor.
July 21
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