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That's a really important question, especially after 20 years of living with PBC and a decade on rifampicin. It's worth having an honest conversation with your specialist about this.

Rifampicin is considered a second-line treatment for PBC-related itching. Over time, some people do find that medications become less Show Full Answer

That's a really important question, especially after 20 years of living with PBC and a decade on rifampicin. It's worth having an honest conversation with your specialist about this.

Rifampicin is considered a second-line treatment for PBC-related itching. Over time, some people do find that medications become less effective, and long-term use of rifampicin does carry some monitoring considerations. Here are some signs it may be worth reviewing with your doctor:

- Your itching has returned or worsened despite taking it consistently
- Your liver function blood tests have changed
- You're experiencing new or unusual side effects

Because rifampicin can, in rare cases, affect the liver and kidneys over time, regular blood tests are really important — especially after long-term use.

If it does seem to be losing effectiveness, there are other options to explore, including opioid antagonists, so you wouldn't be without alternatives. Your specialist is best placed to assess whether rifampicin is still doing its job for you.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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