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They think there might be a link with post-viral inflammatory surges (cytokines like TNF-α and IFN-γ) leading to new-onset PBC / PBC + AIH after recovering from a COVID-19 infection.
https://www.google.com/goto?url=CAESgwEB6zswFT-...
https://pmc.ncbi.nlm.nih.gov/articles/PMC9597224/
https://www.scielo.br/j/acrep/a/kqS4SZ48y
Pippa, I have often wondered about the Covid connection. I had Covid 4 times and can't recall having a UTI in the last 60 years! After Covid, my liver panel test began to change and after a year of test to try to figure out what was wrong I was finally diagnosed in late 2023 by a mitrochondrial DNA test.
@A myPBCteam Member same I haven’t had UTI, used hair dye etc in last 35 years. Never smoked or use nail polish, no HRT…
I definitely suspect it was my trigger. I had Covid in 21, 22, 23 and 24. After my 22 infection I experienced six months of extreme fatigue, and regular sudden onsets of grey skin and puffy face and sudden fatigue. I was never quite the same again after that. After 24 infection that same cycle happened again, investigations found elevated liver enzymes in June 25 and then I was diagnosed in March 26.
That's a really understandable question, especially given how much COVID has affected people with chronic conditions. However, current research on environmental triggers for PBC doesn't specifically identify COVID infection as one of them.
The infections most strongly linked to triggering PBC are urinary tract infections Show Full Answer
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