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October 17
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A myPBCteam Member

@A myPBCteam Member this can happen for some people. They will probably put you on one of the second line therapies. Mine dropped on urso but not back to normal - so I just started a second line therapy which in trials of combining with urso saw 67% of people drop into normal range.

Professor David Jones explains this situation and the second line therapies very well in his book ‘PBC The Definitive Guide for Patients with Primary Biliary Cholangitis: 2026 Edition’

I recommend it - make sure you buy the 2026 edition - it’s available on Amazon and others.

October 17 (edited)
myPBCteam

It's completely understandable to feel frustrated when you've been taking Urso for several months and aren't seeing the results you hoped for. You're definitely not alone in this experience — other myPBCteam members have shared similar concerns about their numbers not responding as expected.

The good news is that your Show Full Answer

It's completely understandable to feel frustrated when you've been taking Urso for several months and aren't seeing the results you hoped for. You're definitely not alone in this experience — other myPBCteam members have shared similar concerns about their numbers not responding as expected.

The good news is that your upcoming appointment on 11/2 is the perfect opportunity to dig into this with your hepatologist. Some things worth bringing up include:

- How your liver tests (ALP, AST, ALT, bilirubin) have trended over the full period
- Whether any side effects or other factors might be affecting how the medication works
- Whether a dosage adjustment or an additional treatment might be appropriate It's also worth knowing that some medications, including cholestyramine, aluminum-based antacids, certain cholesterol drugs, estrogens, and some birth control pills, can interfere with how Urso works. If you take any of these, it's worth mentioning to your doctor.

Hang in there — you're doing the right thing by staying on top of your monitoring and keeping that appointment. 💪

October 17

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