List of Treatments for PBC

Below is a listing of treatments and therapies for PBC. Click on one to read more information or connect with others currently using it.

Ocaliva (Obeticholic Acid)

Ocaliva was voluntarily pulled from the U.S. market in September 2025 following a request from the U.S. Food and Drug Administration (FDA). New FDA safety data showed the drug may cause serious liver injury — including… read more

Opioid Antagonists

Overview
Opioid antagonists are medications that can help relieve itching associated with primary biliary cholangitis (PBC). Doctors may prescribe opioid antagonists, such as naloxone or naltrexone, as a third-line… read more

Pilocarpine Hydrochloride Ophthalmic Solution

Overview
Pilocarpine hydrochloride ophthalmic solution (pilocarpine ophthalmic) is a drug approved by the U.S. Food and Drug Administration (FDA) that is sometimes prescribed off-label to help relieve dry eyes and dry… read more

Rifampin

Overview
Rifampin is a prescription drug approved by the U.S. Food and Drug Administration (FDA) which is sometimes prescribed off-label to treat itching associated with primary biliary cholangitis (PBC). Rifampin is… read more

Sertraline Hydrochloride (Zoloft)

Overview
Sertraline hydrochloride is a medication approved by the U.S. Food and Drug Administration (FDA) to treat depression. Sertraline may be prescribed off-label to help reduce itching and boost overall well-being… read more

Statins

Overview
Statins are a class of drugs that reduce cholesterol in the blood. Statins are sometimes prescribed to treat the high cholesterol that can be a complication of primary biliary cholangitis (PBC). Statins are… read more

Ursodiol

Overview
Ursodiol — also known as ursodeoxycholic acid or UDCA — is a drug used to treat people living with primary biliary cholangitis (PBC). The U.S. Food and Drug Administration (FDA) has approved three formulations… read more

Vitamin Supplements

Overview
Balanced nutrition is important for maintaining liver function with primary biliary cholangitis (PBC). Getting necessary vitamins from food is more beneficial than taking supplements, but this might not be… read more

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myPBCteam is not a medical referral site and does not recommend or endorse any particular provider or medical treatment. No information on myPBCteam should be construed as medical and/or health advice.

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