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No, PBC is not the only condition that causes positive AMA and ANA. While antimitochondrial antibodies (AMA) are highly specific to PBC, with around 95% of people with PBC testing positive, they can rarely appear in other diseases. Antinuclear antibodies (ANA), on the other hand, are less specific and can be found in Show Full Answer

No, PBC is not the only condition that causes positive AMA and ANA. While antimitochondrial antibodies (AMA) are highly specific to PBC, with around 95% of people with PBC testing positive, they can rarely appear in other diseases. Antinuclear antibodies (ANA), on the other hand, are less specific and can be found in various autoimmune diseases like lupus and rheumatoid arthritis.

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