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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Have anyone try the new meds.. Livdeizi are Iqirvo. If so what have the side affects you have had ?

A myPBCteam Member asked a question 💭
Shreveport, LA

I know one can cause myopathy of the muscle. Which I already have. I been approved for both of them.

May 4, 2025
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A myPBCteam Member

No replies??? I wanted to know also. My Dr is thinking of putting me on one of those. But they didn't mention that one of those takes 6% from your bone density. So they are working on building my density which is not good already just so the drug can take it.
Anyone got something to add??

May 4, 2025
myPBCteam

Both Livdelzi (seladelpar) and Iqirvo (elafibranor) were recently approved in 2024 for PBC treatment. These medications can be taken either alone or in combination with UDCA if you're not getting optimal results from UDCA alone.

For Livdelzi (seladelpar), clinical trials have shown positive results with patients reporting Show Full Answer

Both Livdelzi (seladelpar) and Iqirvo (elafibranor) were recently approved in 2024 for PBC treatment. These medications can be taken either alone or in combination with UDCA if you're not getting optimal results from UDCA alone.

For Livdelzi (seladelpar), clinical trials have shown positive results with patients reporting improvements in fatigue, sleep problems, and itching. It can be taken with or without food. For Iqirvo (elafibranor), which is taken once daily by mouth, common side effects include gastrointestinal issues, weight changes, abdominal pain, nausea, and diarrhea. As of December 2024, there's a safety update recommending close monitoring of liver tests, as some cases of liver injury have been reported in people without cirrhosis.

Given your existing muscle condition, it's crucial to work closely with your healthcare provider to monitor any side effects. Always report any new symptoms or side effects to your healthcare team so they can adjust your treatment plan accordingly.

May 4, 2025
A myPBCteam Member

I tried Iqirvo but the muscle pain is awful.

May 7, 2025
A myPBCteam Member

Obsolete?! My doctor has been trying to put me on that for almost a year now. But because of the cost( too expensive for me) the group want me on Urso for a year before they approve Octavia.

May 7, 2025
A myPBCteam Member

I have not. If you do, let us know how it goes. I was on Ocaliva for a couple of years and my all phos numbers came down nicely. However, my liver doc told me it is already obsolete. I'm happy that research is happening for PBC. It was a long time coming.
Best wishes to you on this journey. May you have slow progression, as most of us do. Hugs~

May 4, 2025

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