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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myPBCteam Member asked a question 💭
Hampshire, England
October 10, 2025
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A myPBCteam Member

Hello Jenny, Definitely use caution with Immodium and other OTC products. The liver metabolizes many medications, including Immodium (loperamide). The liver also rids (or clears) toxins and drug metabolites from the body. When the liver is essentially 'under attack' such as by PBC, any resultant insult (damage/dysfunction) can disrupt this normal function. The metabolites/toxins can accumulate and cause some havoc within the body. In addition, Immodium can affect secretions from the gall bladder and pancreas. Should there be liver dysfunction, loperamide metabolites can even affect the brain, causing confusion and additional entities. Your physician has a grasp on your Stage and degree of Liver involvement. It would be prudent to consult with them. Wishing You All the Best!

October 14, 2025 (edited)
A myPBCteam Member

I have taken modicum my whole life. Then was diagnosed with PBC. The diarrhea was worse. Took my Immodium. Started getting scary symptoms. Can't take them anymore for my body. But my GI encouraged me to take it. So I just had to change brands. I bought an off brand and not having any problems.

October 10, 2025
myPBCteam

When taking any medications with PBC, it's important to check with your healthcare provider first. Since medications are processed by the liver, your doctor needs to evaluate if specific medications are safe for your situation.

The timing of medications is particularly important for people with PBC. If you need to take Show Full Answer

When taking any medications with PBC, it's important to check with your healthcare provider first. Since medications are processed by the liver, your doctor needs to evaluate if specific medications are safe for your situation.

The timing of medications is particularly important for people with PBC. If you need to take Imodium, make sure to discuss with your doctor:
• The appropriate dosage
• When to take it in relation to your other PBC medications
• Any potential interactions with your current treatments, especially UDCA
• How it might affect your liver function Remember to always:
• Keep track of any symptoms you experience
• Maintain regular checkups with your healthcare team
• Report any unusual side effects immediately
• Never start a new medication without consulting your hepatologist first

Your hepatologist is the best person to advise on medication safety, as they understand your specific PBC condition and can monitor how your liver responds to different treatments.

October 10, 2025

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