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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

What are some of other peoples AST/ ALT and Alkaline Phosphate numbers with PBC . I’m curious if mine are very high or low compared to other

A myPBCteam Member asked a question 💭
October 31, 2025
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A myPBCteam Member

My numbers on 10-8 were alp 154, ast 46, alt 101. I was on Iqirvo at time and while alp went down five other numbers jumped up. I’m about ready to stop all of this.

November 4, 2025
A myPBCteam Member

Katie, you should have access to all your NHS results. Have a look at this link: https://www.nhs.uk/nhs-services/online-services...

View your test results
View your test results
https://www.nhs.uk/nhs-services/online-services/view-your-test-results/
November 2, 2025
myPBCteam

What are typical AST/ALT and alkaline phosphatase levels in people with PBC?

It's completely natural to wonder how your numbers compare! While specific ranges vary from person to person, here's what's generally seen in PBC:

Alkaline Phosphatase (ALP)
- Normal range is typically 44-147 international units per liter
- PBC Show Full Answer

What are typical AST/ALT and alkaline phosphatase levels in people with PBC?

It's completely natural to wonder how your numbers compare! While specific ranges vary from person to person, here's what's generally seen in PBC:

Alkaline Phosphatase (ALP):
- Normal range is typically 44-147 international units per liter
- PBC is diagnosed when ALP is at least 1.5 times higher than normal (so around 220+ IU/L)
- Some people have ALP levels much higher than this, while others may be closer to the diagnostic threshold
- Lower ALP levels after treatment are usually linked to better long-term outcomes

AST and ALT:
These liver enzymes check for inflammation or damage and are measured alongside ALP. The levels vary widely among people with PBC depending on disease stage and treatment response.

What affects these numbers:
- Stage of disease progression
- How well you're responding to treatment
- Presence of inflammation or scarring
- Other health factors

Your doctor uses these numbers along with other tests like bilirubin, albumin, and platelet count to get the complete picture of your liver health. If you're concerned about your specific numbers, discussing them with your hepatologist or gastroenterologist can help put them in context with your overall health.

October 31, 2025
A myPBCteam Member

My ALK PHOS is 220, my AMA is POS and my AMA Titer is 1:320, if you don't mind me asking what's your AMA Titer? Thank you

November 17, 2025
A myPBCteam Member

Never started it. I’m very scared of side effects. I’m not a good patient I question everything. I also do a lot of research. Probably to my detriment

November 16, 2025

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