Connect with others who understand.

  •   Learn from expert-reviewed resources
  •   Real advice from people who’ve been there
  •   People who understand what you’re going through
Sign Up Log In
All Resources Treatments A-Z Personal Assistant Help Center Crisis
Powered By
Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Has anyone tried wellbutrin 150mg once daily in AM for fatigue and mood?

A myPBCteam Member asked a question 💭

I started taking wellbutrin 150mg/day first thing in the morning to help with fatigue and mood. I felt like lazarus rising from the dead the first 2-3 months but that feeling has normalised. I take 7.5mg mirtazapine before bed to help with sleep/itching. I found it helps. Has anyone else tried this regimen?

December 3, 2025
 · 
Reactions
myPBCteam

Has anyone else tried Wellbutrin 150mg once daily in the morning for fatigue and mood, along with mirtazapine before bed?

It's great that you experienced significant improvement in your fatigue and mood during those first few months! It's common for the initial "wow" effect of medications to level off as your body adjusts Show Full Answer

Has anyone else tried Wellbutrin 150mg once daily in the morning for fatigue and mood, along with mirtazapine before bed?

It's great that you experienced significant improvement in your fatigue and mood during those first few months! It's common for the initial "wow" effect of medications to level off as your body adjusts, though they may still be providing benefit.

While the search results don't specifically mention Wellbutrin or mirtazapine for PBC fatigue, they do highlight that fatigue management often requires a multifaceted approach. Depression can significantly impact energy levels in people with PBC, so addressing mood alongside fatigue makes sense.

Your combination approach—targeting fatigue and mood in the morning while addressing sleep and itching at night—follows good logic. Since mirtazapine is helping with both sleep and itching, you're tackling two common PBC symptoms that can worsen fatigue.

If you feel the fatigue-fighting effect has diminished, it's worth discussing with your doctor. They might suggest adjusting the timing, dosage, or exploring additional strategies like:

- Increased physical activity (even short walks)
- Light therapy in the morning
- Reviewing other medications that might contribute to fatigue
- Checking for nutritional deficiencies common in PBC

Keep communicating with your healthcare provider about what's working and what isn't—managing PBC fatigue often requires ongoing adjustments.

December 3, 2025
A myPBCteam Member

I was diagnosed with PBC in April. I am on the generic of Wellbutren. Its called BUPROPION. Both 150 mg in the morning and 200mg at night.
I have been on both of those for over 10 yrs now.
I am also taking ursodiol. As of these last few weeks on the medicine I have not had any issues. 🙏❣️

May 27
A myPBCteam Member

I am newly diagnosed with PBC as of last month,before I found my gastroenteritis I was seeing another primary care dr who tested me every 3 months ,and every 3 months showed extremely high liver enzymes,so I have had symptoms WAY before i got diagnosed,but I also take wellbutrin 300mg xl once everymorning, and like you also mirtazapine 15mg (never met someone taking the same lol) and it helps me tremendously. But I've been taking those for atleast years now amongst other meds mirtazapine has been a godsend when it comes to sleep. For me the wellbutrin is like a morning cup of coffee.

December 21, 2025

Related Questions

View All

What are symptoms you experience with PBC?

myPBCteam asked a question 💭
San Francisco, CA
December 28, 2023

Fatigue and Primary Biliary Cholangitis: 6 Tips To Help
3 Ways To Deal With PBC Fatigue and Stress (VIDEO)
What Causes Fatigue With PBC?