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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Ok, all of my liver enzyme tests came back good including my AMA which was negative. I still have the characteristic itching and fatigue.

A myPBCteam Member asked a question 💭
Shohola, PA

Should I just assume that I don't have PBC or still see a hepatologist to make sure? Don't know why I am so itchy on my palms, wrists, soles of feet and all over.

February 21
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Reactions
A myPBCteam Member

Thank you Verdie - I never thought of using rubbing alcohol. I do use an anti-itching cream which seems to help. and if it's a really bad itching day for me, I'll take a Zyrtec pill which takes the itch away completely for me. And, it doesn't make me tired.

March 3
A myPBCteam Member

That's one of the top symptoms of PBC. It usually affects my hands, arms, back, and the area under by breasts the most. The intensity will vary. I use aveeno bath powder to help control it when it's bad. I've tried countless creams, but I find that using plain rubbing alcohol seems to work best for me.

March 2
myPBCteam

Should you still see a hepatologist even with negative AMA and normal liver enzymes?

It's worth seeing a hepatologist to be sure. About 5 percent of people with PBC are AMA-negative, meaning they don't have these antibodies in their blood but still have the condition. Your symptoms of itching on your palms and soles of Show Full Answer

Should you still see a hepatologist even with negative AMA and normal liver enzymes?

It's worth seeing a hepatologist to be sure. About 5 percent of people with PBC are AMA-negative, meaning they don't have these antibodies in their blood but still have the condition. Your symptoms of itching on your palms and soles of feet, along with fatigue, are very characteristic of PBC.

Even with normal liver enzyme levels right now, if you're AMA-positive (or have symptoms), doctors may recommend ongoing monitoring every six to 12 months. This helps catch any liver changes early, since PBC can develop over time.

A hepatologist can:
* Order additional tests like imaging (ultrasound or MRCP) to check your bile ducts
* Consider a liver biopsy if needed to confirm or rule out PBC
* Look for other causes of your itching and fatigue
* Set up a monitoring plan if PBC is suspected but not confirmed yet

The itching pattern you describe—especially on palms and soles—is classic for PBC-related pruritus. It's important to investigate this further rather than assume everything is fine, since early diagnosis and treatment can help slow liver damage.

February 21

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