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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
March 18
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A myPBCteam Member

I too have no hair on my legs and my hair on my head has thinned considerably. :(

March 18
myPBCteam

Are you experiencing hair loss on your legs while taking ursodiol?

Hair loss isn't officially listed as a common side effect of ursodiol, but some myPBCteam members have shared that they noticed hair thinning or increased shedding after starting the medication. The scientific evidence directly linking ursodiol to hair loss Show Full Answer

Are you experiencing hair loss on your legs while taking ursodiol?

Hair loss isn't officially listed as a common side effect of ursodiol, but some myPBCteam members have shared that they noticed hair thinning or increased shedding after starting the medication. The scientific evidence directly linking ursodiol to hair loss is limited, but individual experiences vary.

There are several possible explanations for what you're noticing:

PBC-related factors:
- Nutrient deficiencies (vitamins A, D, E, K, iron, biotin) due to reduced bile flow
- Autoimmune activity that can disrupt hair growth cycles
- Chronic inflammation and stress from living with PBC

Other potential causes:
- Age-related hair thinning
- Iron deficiency anemia
- Thyroid issues (common with PBC)
- Hormonal imbalances
- Chronic fatigue and stress

It's worth talking to your doctor about what you're experiencing. They can check for nutrient deficiencies, thyroid problems, or other factors that might be contributing to the hair loss on your legs.

In the meantime, eating a nutrient-rich diet with healthy fats, lean proteins, and colorful fruits and vegetables may help support hair health.

March 18

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