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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myPBCteam Member asked a question 💭
Ottawa, ON

I am trying to increase my ursodiol strenght from 500 to 750 but feeling worse; and have been toying with 500 to 750ml each day.
My last symptom a couple of weeks ago and has not stopped since is a fowl taste in my mouth all the time. Does anybody else have this?

April 5
 · 
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A myPBCteam Member

I have had my URSO increased and have been experiencing very dry mouth with a weird taste as well.

April 8
myPBCteam

Are you experiencing a foul taste in your mouth after increasing your ursodiol dose?

A persistent bad taste in your mouth isn't listed among the most common side effects of ursodiol, but that doesn't mean it can't happen. The most commonly reported side effects include:

* Diarrhea
* Stomach pain
* Nausea
* Dizziness
* Show Full Answer

Are you experiencing a foul taste in your mouth after increasing your ursodiol dose?

A persistent bad taste in your mouth isn't listed among the most common side effects of ursodiol, but that doesn't mean it can't happen. The most commonly reported side effects include:

* Diarrhea
* Stomach pain
* Nausea
* Dizziness
* Back pain
* Changes in stool
* Loss of appetite
* Indigestion

Since you're feeling worse overall after trying to increase your dose from 500 to 750 mg, this is definitely something to discuss with your doctor. They may need to adjust your dosing schedule or help you increase more gradually to reduce side effects.

Don't change your medication dose without talking to your healthcare provider first. If you're having significant side effects, they can work with you to find the right approach—whether that's adjusting how you take it, changing the dose more slowly, or exploring other options.

The timing of this symptom appearing right when you increased your dose suggests it could be related, so it's worth bringing up at your next appointment.

April 5

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