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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Urso after a certain time does it become intolarable

A myPBCteam Member asked a question 💭
May 25
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A myPBCteam Member

The first thing I noticed how often you took urso. I was given the wrong amount . My GI doc said that it should go by your weight. I take 300mg twice a day. I never had a reaction from it at all. My indid not approve Livdelzi so now I take a generic one. No problems from it either I'm still adjusting to it noticed I'm more sleepy but I still get things done.

May 28
A myPBCteam Member

The answer for me is yes. I was put on Urso about a year and a half maybe two years ago. I was supposed to take it 3 x daily. After a week I went to 2 and eventually 1 daily. About 8 months ago I stopped. The nausea, cramping and stomach upset was intolerable. Unfortunately my numbers went up and the PA told me I really needed to go back to taking it 3 x daily. I tried again for about a week and told them I just couldn’t. I have started Livdelzi and am ok with it so far. It’s only been a week or so but I’m taking it as a positive sign. Good luck.

May 28
myPBCteam

Can Urso become intolerable over time? That's a really common concern, and the short answer is: it varies from person to person.

Some people do find that side effects ease up after the body adjusts to the medication. Others may find certain side effects persist or feel harder to manage over time.

Common side effects of Show Full Answer

Can Urso become intolerable over time? That's a really common concern, and the short answer is: it varies from person to person.

Some people do find that side effects ease up after the body adjusts to the medication. Others may find certain side effects persist or feel harder to manage over time.

Common side effects of Urso include:

- Diarrhea
- Stomach pain or bloating
- Nausea
- Dizziness
- Back pain
- Loss of appetite
- Changes in stool A myPBCteam member shared that their doctor agreed to lower the dose when side effects became too much, and as long as liver numbers stayed stable, that worked well for them. Another member found that switching to taking Urso at night, and avoiding high-fat foods, made a big difference.

If Urso is feeling increasingly hard to tolerate, it's worth having an honest conversation with a doctor. They may suggest:

- Adjusting the dose
- Changing the timing of when it's taken
- Exploring alternative PBC medications

Never adjust or stop the medication without speaking to a doctor first, as Urso plays an important role in protecting the liver and slowing PBC progression.

May 25
A myPBCteam Member

Urso doesn't bother me now. When I first started taking it, it took my body about a month to adjust to the medicine. It was so bad that I considered taking some time of work until my body could tolerate the medicine.

May 28

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