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Real members of myPBCteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myPBCteam Member asked a question 💭
Manley Hot Springs, AK

Been on Zepbound for 6 months don’t feel any different on the PBC side. Wondering if anyone is taking also

July 20
 · 
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myPBCteam

That's a really important question, and it's completely understandable to want to know if a medication like Zepbound is safe when you're already managing a liver condition like PBC.

Unfortunately, Zepbound (tirzepatide) isn't covered in the available PBC-specific resources, so there isn't enough information here to give a Show Full Answer

That's a really important question, and it's completely understandable to want to know if a medication like Zepbound is safe when you're already managing a liver condition like PBC.

Unfortunately, Zepbound (tirzepatide) isn't covered in the available PBC-specific resources, so there isn't enough information here to give a reliable answer about its safety for people with PBC specifically. What is strongly recommended is speaking directly with your hepatologist (liver specialist) before starting any new medication. This is especially important with PBC because:

- The liver processes most medications
- PBC can affect how drugs are metabolized
- Some medications can worsen liver damage or interact with PBC treatments like UDCA

Your hepatologist can review your current liver enzyme levels and overall liver health to determine whether Zepbound would be safe for your specific situation. Don't start or stop any medication without checking with them first.

July 20

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